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Tri-Synergizer packets
Tri-Synergizer packets
Bottles of Protandim Tri-Synergizer
Bottles of Protandim Tri-Synergizer
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Protandim® Tri-Synergizer*

Protandim Nrf2, NAD, and NRF1 Synergizers effectively reduce oxidative stress, support mitochondria function, increase sirtuin activity, and target cell signaling pathways to fight the effects of aging.

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Tri-Synergizer Packets Tri-Synergizer Bottles
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The Protandim Family

LifeVantage is a company using science to approach health differently – we are focused on understanding the major scientific theories of aging and addressing the root causes to be able to take a proactive approach to increasing healthspan.

We specialize in Nutrigenomics – using Nutrients to affect gene expression. Put simply, we use nutrients to tell our bodies how to help themselves.

It all started almost half a century ago, when science proved that our bodies have built in abilities to keep themselves healthy. Two decades ago, a discovery proved that we could tap into those abilities by communicating with our genes through nutrients.

That discovery is the reason LifeVantage exists. The discovery that five plant extracts, when used together, could tell your body to produce antioxidants*, opened a whole new world of possibilities. Since then we have been relentlessly working to communicate with additional genes associated with the major scientific theories of aging, and each subsequent discovery becomes a member of our flagship Protandim line of synergizers.


Graph showing results of NAD gene activation study
Graph showing results of NRF1 gene activation study
Graph showing results of Nrf2 gene activation study

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Top FAQ's

  • Yes, if you purchase the Vitality Stack (packets/bottles), Activated Essentials, or the Ultimate Stack, you will receive free shipping. If you add additional products to your order when ordering these stacks, your entire order will ship for free.

  • Yes, we perform exhaustive testing to verify that all LifeVantage products meet or exceed quality standards. The Quality Control measures implemented by LifeVantage exceed industry standards. We rigorously test every lot of product for identity, potency, microbial contamination, pesticides and heavy metals, and physically audit manufacturing facilities and raw material suppliers.

  • Please consult your physician if you are taking any medication before use.

  • Protandim Nrf2 and Nrf1 Synergizers work together to reduce oxidative stress and support mitochondria biogenesis and function. With the addition of NAD Synergizer, we can now target other biochemical pathways known to support healthy aging and increased health span.

  • Researchers and scientists agree that aging is the natural result of overall cellular deterioration. One major way this occurs is through exposure to free radicals, other oxidants, and toxicological insults. It is impossible to avoid these exposures because the food you eat, the air you breathe, our modern lifestyles, stress, and even exercise, but we can do certain things to maintain our health as we age. The human body naturally fights these insults by producing its own antioxidant and detoxification enzymes through Nrf2-dependent mechanisms. However, as we grow older, Nrf2 works less efficiently. That’s where Protandim® Nrf2 Synergizer TM plays a critical role. It supports these Nrf2-dependent mechanisms to boost the body’s production of antioxidant and detoxification enzymes. Another natural phenomenon relating to the aging process is our mitochondria (the cell’s powerplant) begins working less efficiently. Less efficient mitochondria produce less energy and produce excess free radicals and other oxidants. Supporting overall mitochondrial function is important to promote overall health as we age. Protandim NRF1 was designed to both increase mitochondrial number and provide ingredients shown to support mitochondrial health. Lastly, another major significant effect of the aging process is a decline of cellular NAD levels and reduction of sirtuin activity. Sirtuin activity has been shown to play a major roll in supporting overall health. Protandim® NAD Synergizer TM was designed to support NAD levels and sirtuin activity. Thus, taking the entire Protandim family of products will help support all of these significant aspects of the aging process.*


    • Helps the body detoxify genes, keeping the master blueprint of the cell's function intact *
    • Reduces oxidative stress by 40% in just 30 days *
    • Significantly reduces cellular stress through Nrf2 activation *
    • Produces enzymes capable of neutralizing more than 1,000,000 free radicals **
    • Helps to regulate survival genes *
    • Supports the body's natural ability to repair and rejuvenate its own cells *
    • Improves performance through energy function *
    • Enhances cellular health - cells function at peak performance *
    • Increases cellular energy (ATP) *
    • Supports healthy longevity *
    • Supports autophagy (removal of cellular waste) *
    • Improves mental focus and concentration *
    • Supports positive mood and motivation *
    • Boosts mental and physical energy *
    • Supports body's healthy inflammatory response *
    • Maintain cholesterol levels already in the healthy range *
    • Supports healthy vascular system *

Label Info & Usage

Please view individual products for their label and ingredient information.


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* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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