Discover how to benefit your health and reduce the signs of the normal aging process with Protandim® NAD Synergizer™ from LifeVantage.

What if you could combat the normal effects of aging by maintaining a healthy vascular system, healthy cholesterol levels already in the normal range, and healthy mood? Don’t you hope to stay healthy and happy for a longer percentage of your life? Sounds like a no-brainer!

All of this can be yours if only you reduce your caloric intake by 40-60%. Yup, you heard that right. And yes, it does sound miserable.

Over the last several decades, scientists have discovered that extreme caloric restriction extends people’s health. In fact, it’s the only method that’s been scientifically shown to extend life. Until recently, experts didn’t know why—they just had evidence of the effect. 

Unfortunately, it’s difficult to maintain the balance between low calories and high nutritional density—and that’s even before taking into account that eating only 600-800 calories per day can be very uncomfortable! Anyone would likely be hangry in that state. So even though the scientific community has been aware of the positive effect on aging, few individuals choose to adopt this as their new lifestyle. 

Fortunately, Protandim® NAD Synergizer™* offers another option. Let’s dive into the discoveries that lead up to the development of this ground-breaking product.

NAD and Sirtuins: The Secret to “Anti-Aging”

As scientists sought to understand why extreme caloric restriction had the effects it does, they discovered something interesting. It was increasing the production and activity of newly discovered proteins called sirtuins. And to add to the discovery, when they removed sirtuins from the equation, extreme caloric restriction no longer had the health benefits previously observed. 

Sirtuins were the key. 

The discovery of sirtuins’ role in the health benefits of caloric restriction set off a flurry of research on these incredible proteins. Sirtuins were shown to provide a litany of important health benefits (such as a healthy vascular system, healthy cholesterol levels, removal of cellular waste, and improved concentration, mood, motivation, and energy). 

Everyone has some level of sirtuins in their body, but in the process of aging, systems become less effective at signaling and creating these proteins. On average, sirtuins are reduced by about 60% over time. By knowing how sirtuins support better health, scientists can find ways to replicate some of the effects of extreme caloric restriction without the deprivation of a low-calorie diet.

Further research on sirtuins showed that they are tied to NAD (short for nicotinamide adenine dinucleotide). In fact, sirtuin pathways are only activated if they are in the presence of NAD. NAD is an energy-promoting signal protein in the mitochondria of your cells (this means it is essential for producing the energy your body needs to function on a cellular level). NAD allows your cells to communicate, allowing your body to work smoothly both on a micro and macro level. NAD is critical for multiple aspects of cellular functioning, and one of them is to increase the production of sirtuins. 

Researchers have discovered that if we increase the production of NAD, sirtuin production will also increase, leading to the benefits of calorie restriction without the discomfort. The proprietary blend of NAD promoters in Protandim® NAD Synergizer™, taken daily, can give you the boost of sirtuins you need to maintain your vitality.*

Let’s take a quick look at the numbers: extreme caloric restriction can increase sirtuin production by 94%. In contrast, competitors, who seek to replicate this effect by selling supplements with precursors to NAD, have only managed to increase sirtuin production by 2%.

However, taking Protandim® NAD Synergizer™ has been shown to increase sirtuin production by 100% within 24 hours of your first dose!* 

The Proprietary Blend in Protandim® NAD Synergizer™*

Our unique ingredient blend packs powerful results that can only be achieved by using all four components together. The synergistic effect of these ingredients leads to the remarkable increase in sirtuins that exceeds the effect of extreme calorie restriction.* 

Protandim® NAD Synergizer™ contains these active ingredients: 

Wasabi (Wasabia japonica) Rhizome Powder

Wasabi, a vegetable related to other cruciferous plants like broccoli and cabbage, is native to shady, humid climates throughout the world. You may have eaten it as a condiment with sushi or other cuisines. However, its benefits go far beyond its characteristic spicy flavor. The root, or rhizome, of the wasabi plant contains a high concentration of compounds known as isothiocyanates. Isothiocyanates give wasabi its powerful flavor and also affect metabolic processes throughout the body. In addition, wasabi has been found to support healthy inflammation responses. There is also some evidence that wasabi can be protective of bone structure and can promote brain health.*

Olive (Olea europaea) Leaf Extract

Olive leaf extract is exactly what it sounds like—a compound extracted from the leaves of an olive tree. Olive leaves contain a compound called hydroxytyrosol, which helps maintain existing normal cholesterol levels, promotes a healthy inflammation response, and promotes gut health. Hydroxytyrosol also ramps up antioxidant activity and promotes autophagy, the cell’s disposal of waste products. Other potential benefits of olive leaf extract include helping to maintain normal blood pressure, weight loss, and supporting existing normal levels of insulin.*

Cuprous Niacin

Cuprous niacin is the complex between niacin (or vitamin B3) and activated copper. Copper is essential for many cell functions, including iron metabolism, energy production, and functioning nerve pathways. Niacin is one of the crucial  ingredients needed to synthesize NAD, the compound that increases the production of sirtuins. Niacin consumption can prevent nutritional deficiencies and maintain existing normal cholesterol levels. Niacin promotes memory, energy, positive mood, proper digestion and healthy skin. In addition to protecting against all these conditions, niacin can maintain normal triglycerides, boost brain function, and help maintain healthy skin.*


Theacrine, a molecular cousin of caffeine, increases cellular energy, which enables your body to function more efficiently. Theacrine activates two neural pathways: the dopaminergic and the adenosinergic pathways. Dopaminergic pathways are the reward system in the brain—by increasing dopamine, individuals feel an increased sense of well-being and pleasure. Theacrine prevents dopamine from being reabsorbed, allowing more of it to flow through your system and increasing your long-term sense of well-being and motivation. Theacrine may also affect the neurotransmitters serotonin and norepinephrine, which supports a healthy mood. The second set of neural pathways influenced by theacrine is adenosinergic pathways, which affect alertness. Theacrine helps you feel more alert, but without the familiar side effects of caffeine such as jitters, palpitations, and irritability. Theacrine also does not cause withdrawal symptoms the way caffeine does if it is stopped abruptly. Theacrine also maintains existing normal cholesterol levels and supports a healthy inflammation response. Some evidence suggests that it may help with normal aches and pains from everyday activity.*

All of these natural ingredients work together to create Protandim® NAD Synergizer™ and increase NAD production, which leads to higher sirtuin levels, a key factor in maintaining health as we continue to age.* 

If you’re seeking to support your overall health without the discomfort of extreme calorie restriction, Protandim® NAD Synergizer™ may be your solution. Protandim® NAD Synergizer™ supports a healthy vascular system; cholesterol levels already in the normal range; increased energy; and improved mood, concentration, focus, and motivation. In addition, it promotes clean-up of cellular waste byproducts. Combining this supplement with positive habits can boost the quality of your life and health more than simple calorie restriction or attempting to replace NAD components, like our competitors’ products do.* 

Take control of your health and live your life to the fullest with Protandim® NAD Synergizer™. Flip the Switch, Feel Better, and Do More!*

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.