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Monday, April 13, 2015

Digestive Health & Cellular Stress


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While it’s difficult to have a serious conversation that involves talk of bowel function, tummy troubles are no laughing matter. In fact, according to the American Nutrition Association, nearly 70 million people suffer from some form of digestive issues every day. Some of these issues include…

  • Heartburn
  • Acid reflux
  • Abdominal pain
  • Bloating
  • Altered bowel habits (i.e., constipation, diarrhea)

And though some of these issues are short term and easy to control with things like lifestyle changes, a number of them can be difficult to manage and may be a sign of more serious gastrointestinal (GI) problems.

So what is it that lies behind those unwanted GI symptoms that, at times, leave you feeling completely miserable? Unfortunately, there doesn’t seem to be one simple answer, though there may be one major offender – OXIDATIVE STRESS. According to recent research, increased exposure to oxidative stress can contribute to GI dysfunction.

How so? Short answer – it’s complicated and there is still a lot to be learned. That being said, these new findings shed light on the ways in which overexposure to oxidative stress might interrupt normal gut function.

In order to understand the its impact on your gut, let’s do a quick refresher of what normal GI function looks like.

The Inner Workings of Your Gut

Your GI tract is a long tube that starts at the mouth and ends at your behind. When stretched out, the whole digestive tract is about 30 feet long! To do its job, it requires cooperation from many organs including – the esophagus, stomach, small intestine, colon (large intestine), rectum, and anus. It also requires the help of the pancreas, liver, gallbladder and – believe it or not – the nearly 100 trillion microorganisms found throughout the gut. The function of your GI tract is to:digestivesystem

  • Consume and digest food
  • Absorb the nutrients contained in those foods
  • Excrete waste leftover from the digestive process
  • Act as a protective barrier against harmful substances

In order for these functions to occur, your gut must have the following –

Adequate intestinal barrier function

The gut wall forms a barrier between the inside of your body and the external environment. It works hard to allow efficient absorption of nutrients into the body while preventing harmful substances from entering the bloodstream. Tight junctions seal the gap between the intestinal cells and allow the selective movement of nutrients and other substances to cross over into the body. Damage to these tight junctions, and thus the intestinal barrier, is now being recognized as a culprit of gut dysfunction.

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Proper communication between the gut and the brain (the gut-brain axis)

The ‘gut-brain axis’ refers to the communication that occurs between the gut and the brain.

This axis uses four major information carriers to send signals between the gut and the brain.

  • Neural messages
  • Immune messages
  • Endocrine (hormone) messages
  • Microbial (microorganisms) factors

These communication systems are important for several reasons including:

  • Metabolic survival – the brain must interact with the gut to find appropriate food.
  • Protection from harmful substances – the gut must distinguish between useful vs. useless or dangerous ingredients in the foods we eat.
  • Microbial homeostasis – the gut must maintain homeostasis with the microorganisms living within the intestines as they are a key player in supporting nutrition, regulating the immune system, and communicating directly with the brain.

And because each of these systems work together to ensure proper communication, disruption to any one of them may have a significant impact on normal gut function.

Healthy intestinal microorganisms

Over the last 5 years, the importance of the gut microbiome (i.e., microorganisms living in the gut) on human health has become increasingly recognized. As mentioned previously, your gut contains nearly 100 trillion microorganisms, including over 500 different species of known bacteria. These intestineorganismsmicroorganisms, especially bacteria, help to –

  • absorb nutrients,
  • maintain immune function,
  • preserve intestinal barrier integrity,
  • promote motility, and
  • process waste products.

The establishment of gut microorganisms starts at birth, reaches maximum diversity during adolescence, and attempts to remain stable until later in life. So what happens if the composition or distribution of microorganisms change?

New research suggests that a disruption of the 100 trillion microorganisms might be connected to gut dysfunction. What are the sources of disruption? A growing body evidence suggests that factors such as antibiotic use, psychological and physical stress, altered GI motility, and dietary changes can interrupt the normal composition and distribution of gut bacteria.

Putting it all together

So now that you have an understanding of what it takes to maintain normal GI function, let’s go back to oxidative stress and its link to disrupted gut function.

As mentioned above, in order to carry out its day-to-day functions, the gut must have 1) adequate intestinal barrier function; 2) proper communication between the gut and the brain and; 3) healthy intestinal microorganisms. Though research is still in its infancy, current evidence suggests that overexposure to oxidative stress might disrupt each of these three components.

Listed below are some of the ways it is thought to impede normal gut function.

  • Damages intestinal cell structures which could lead to decreased intestinal barrier function.
    • Disrupted intestinal barrier function could then lead to invasion of pathogenic bacteria (i.e., bacteria that can cause infection).
  • Induces significant alterations in the composition of gut bacteria (i.e., decreases beneficial bacteria and increases potentially pathogenic bacteria in the gut).
  • Disrupts communication pathways between the gut and the brain (i.e., the gut-brain axis).

So where does oxidative stress come from?

Here are a few sources of stress that can lead to cellular damage and potentially interrupt normal gut function:

  • Emotional stress (deadlines, relationships, traffic)
  • Physical stress (aging, sleep deprivation, too much or too little exercise, poor nutrition)
  • Environmental stress (air or water pollution)
  • Financial stress (bills)

Struggling with Oxidative Stress? Try Protandim Nrf2®!

According to new research, a strategy for protecting against GI injury from oxidative stress might involve up-regulation of antioxidant enzymes in the GI tract via the Nrf2 pathway.

Protandim’s unique blend of ingredients has been shown to be a powerful stimulator of Nrf2 – the master regulator of the body’s antioxidant and protective response. With increased Nrf2 activity, your body is better equipped to preserve intestinal integrity which is important for optimal gut function.



1. Protects from oxidative stress

  • Activates certain genes that work to increase production of internal protective enzymes and proteins.
  • Helps to maintain proper functioning of the body and promotes optimal health.

2. Might help to promote normal GI function

  • Two ingredients within Protandim (i.e., catechins from the green tea extract and curcumin found in the turmeric extract) have been found to act as intestinal protective agents by reducing free radical production, restoring antioxidant enzyme activity, and decreasing the secretion of cytokines (i.e., molecules that can lead to increased oxidative stress).
  • Might help to prevent disruption of intestinal barrier function, bacterial composition, and communication pathways – all of which are important for normal GI function.

Are you ready to take action?

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