Peer-Reviewed Studies

The Induction of Human Superoxide Dismutase and Catalase In Vivo: A Fundamentally New Approach to Antioxidant Therapy
- Publication:Free Radical Biology & Medicine, Jan. 15, 2006
- Authors: S.K. Nelson, S.K. Bose, G.K. Grunwald, P. Myhill, J.M. McCord, Webb-Waring Institute for Cancer, Aging and Antioxidant - Research, University of Colorado Denver
- In this study Protandim was administered to healthy humans ages 20 to 78 years old. After 30 days, TBARS declined by an average of 40 percent.
- *Protandim eliminated the age-related increase in cell-aging factors by increasing the body's antioxidant defenses.

The Role of Manganese Superoxide Dismutase in Skin Cancer
- Publication:Enzyme Research, March 23, 2011
- Authors: Delira Robbins and Yunfeng Zhao, Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences
- This study used a two-part model to test the effectiveness of Protandim in chemoprevention. In one approach, researchers applied a SOD mimetic topically to mouse skin. In another approach, Protandim decreased tumor incidence and multiplicity by 33 percent and 57 percent, respectively.
- *Protandim may be a novel approach to chemoprevention.

Protandim Attenuates Intimal Hyperplasia in Human Saphenous Veins Cultured Ex Vivo A Catalase-Dependent Pathway
- Publication:Free Radical Biology & Medicine, March 15, 2011
- Authors: B. Joddar, R.K. Reen, M.S. Firstenberg, S. Varadharaj, J.M. McCord, J.L. Zweiler, K.J. Gooch, Department of Biomedical Engineering, Ohio State
- This study examined the biochemical mechanisms that underlie the ability of Protandim to suppress intimal hyperplasia-over-proliferation of cells that line the vessel wall, a common adverse event that limits the effectiveness of vascular surgery. Treatment of human saphenous veins with Protandim blocked intimal hyperplasia and reduced cellular proliferation to that of freshly isolated human saphenous veins.
- *Protandim significantly increased antioxidant enzyme activity in veins while reducing free radical levels, lipid peroxidation and intimal proliferation.

The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice
- Publication:Journal of Deitary Supplements, June 1, 2010
- Authors: M.M. Qureshi, W.C. McClure, N.L. Arevalo, R.E.Rabon, B. Mohr, S.K. Bose, J.M. McCord, B.S. Tseng, University of Colorado Denver, and Mass. General Hospital, Harvard Medical School
- Oxidative damage is thought to be a pertinent factor in the development of Duchenne muscular dystrophy (DMD), the most common and lethal neuromuscular disorder in children. Researchers used surrogate markers and functional measurers in a dystrophin-deficient mouse model of DMD to determine whether Protandim provides any benefit. After six months on Protandim, a 48 percent average decrease in plasma TBARS and a 57 percent decrease in plasma osteopontin was seen, as well as a 35 percent increase in beneficial protective plasma PON1 activity.
- *Protandim improves markers of oxidative stress and fibrosis in muscular dystrophy mice.

Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis As A Model
- Publication:PLoS One, April 22, 2009
- Authors: J. Liu, X. Gu, D. Robbins, G. Li, R. Shi, J.M. McCord, Y. Zhao, Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University
- To investigate whether Protandim can suppress tumor formation by a dietary approach, a two-stage mouse skin carcinogenesis study was performed. At the end of the study, both skin tumor incidence and multiplicity were reduced in the mice on the Protandim diet by 33 percent and 57 percent, respectively compared with those on a basal diet.
- *Induction of antioxidant enzymes by Protandim may be practical for cancer prevention.

Chronic Pulmonary Artery Pressure Elevation is Insufficent to Explain Right Heart Failure
- Publication:Circulation, Nov. 17, 2009
- Authors: H.J. Bogaard, R. Natarajan, S.C. Henderson, C. S. Long, D. Krakauskas, L. Smithson, R. Ockaili, J.M. McCord, N.F. Voelkel, Divisions of Pulmonary and Critical Care, Virginia Commonwealth University
- This study used a lab model of pulmonary hypertension in rats to explore factors contributing to heart failure in animals. Pulmonary hypertension was induced in rats through a drug and by creating an oxygen-poor environment. The animals pre-treated with Protandim experienced strong cardio-protectitive effects.
- *Protandim protected the animals' hearts by increasing the expression of protective genes and preventing the formation of scar tissue.

The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis During Skin Carcinogenesis
- Publication:PLoS One, July 30, 2010
- Authors: D. Robbins, X. Gu, R. Shi, J. Liu, F. Wang, J. Ponville, J.M. McCord, Y. Zhao, Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences
- This study explored the biochemical mechanisms that underlie the ability of Protandim to suppress tumors in mice. That ability was previously demonstrated by the authors in a study involving a mouse two-stage model of chemically induced skin cancer. This study suggested that suppression of p53 and induction of MnSOD may play an important role in the tumor suppressive activity of Protandim.
- *The induction of antioxidant enzymes by Protandim may be a practical and potent approach for cancer prevention.

Synergistic Induction of Heme Oxygenase-1 by the Components of the Antioxidant Supplement Protandim
- Publication:Free Radical Biology & Medicine, Feb. 1, 2009
- Authors: K. Velmurugan, J. Alam, J.M. McCord, S. Pugazhenthi, Division of Endocrinology, Department of Medicine, University of Colorado Denver
- This study explored whether components of Protandim acted in a synergistic manner in certain cells, specifically if it would induce heme oxygenase. When components were tested alone, only curcumin showed minimal induction. Together they produced a strong, synergistic induction.
- *Protandim produced a 300 percent increase in glutathione, a key antioxidant and anti-aging factor. Also, the supplement's patented formula provides a strong synergy much greater than the sum of its parts.

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* Source: PUBMED.GOV

Protandim is a dietary supplement, not a drug. We do not promote or intend to imply or represent that Protandim can prevent, cure, treat or mitigate any disease or class of disease. Protandim is not intended to be an alternative or replacement for any drug or biological product. If you are interested in reviewing the studies, visit www.pubmed.gov and enter "Protandim" in the search box.