The Induction of Human Superoxide Dismutase and Catalase
In Vivo: A Fundamentally New Approach to Antioxidant
Therapy
- Publication:Free Radical Biology & Medicine, Jan. 15,
2006
- Authors: S.K. Nelson, S.K. Bose, G.K. Grunwald, P. Myhill, J.M.
McCord, Webb-Waring Institute for Cancer, Aging and
Antioxidant - Research, University of Colorado Denver
- In this study Protandim was administered to healthy humans ages
20 to 78 years old. After 30 days, TBARS declined by an average of
40%.
- *Protandim eliminated the age-related increase in cell aging
factors by increasing the body's antioxidant defenses.
The Role of Manganese Superoxide Dismutase in Skin
Cancer
- Publication:Enzyme Research, March 23, 2011
- Authors: Delira Robbins and Yunfeng Zhao, Department of
Pharmacology, Toxicology & Neuroscience, Louisiana State
University Health Sciences
- This study used a two-part model to test the effectiveness of
Protandim in chemoprevention. In one approach, researchers applied
a SOD mimetic topically to mouse skin. In another approach,
Protandim decreased tumor incidence and multiplicity by 33% and
57%, respectively.
- *Protandim may be a novel approach to chemoprevention.
Protandim Attenuates Intimal Hyperplasia in Human
Saphenous Veins Cultured Ex Vivo A Catalase-Dependent
Pathway
- Publication:Free Radical Biology & Medicine, March 15,
2011
- Authors: B. Joddar, R.K. Reen, M.S. Firstenberg, S. Varadharaj,
J.M. McCord, J.L. Zweiler, K.J. Gooch, Department of Biomedical
Engineering, Ohio State
- This study examined the biochemical mechanisms that underlie the
ability of Protandim to suppress intimal
hyperplasia-over-proliferation of cells that line the vessel wall-a
common adverse event that limits the effectiveness of vascular
surgery. Treatment of human saphenous veins with Protandim blocked
intimal hyperplasia and reduced cellular proliferation to that of
freshly isolated human saphenous veins.
- *Protandim significantly increased antioxidant enzyme activity
in veins while reducing free radical levels, lipid peroxidation and
intimal proliferation.
The Dietary Supplement Protandim Decreases Plasma
Osteopontin and Improves Markers of Oxidative Stress in Muscular
Dystrophy Mdx Mice
- Publication:Journal of Deitary Supplements, June 1, 2010
- Authors: M.M. Qureshi, W.C. McClure, N.L. Arevalo, R.E.Rabon, B.
Mohr, S.K. Bose, J.M. McCord, B.S. Tseng, University of Colorado
Denver, and Mass. General Hospital, Harvard Medical School
- Oxidative damage is thought to be a pertinent factor in the
development of Duchenne muscular dystrophy (DMD), the most common
and lethal neuromuscular disorder in children. Researchers used
surrogate markers and functional measurers in a
dystrophin-deficient mouse model of DMD to determine whether
Protandim provides any benefit. After six months on Protandim, a
48% average decrease in plasma TBARS and a 57% decrease in plasma
osteopontin was seen, as well as a 35% increase in beneficial
protective plasma PON1 activity.
- *Protandim improves markers of oxidative stress and fibrosis in
muscular dystrophy mice.
Protandim, a Fundamentally New Antioxidant Approach in
Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis As A
Model
- Publication:PLoS One, April 22, 2009
- Authors: J. Liu, X. Gu, D. Robbins, G. Li, R. Shi, J.M. McCord,
Y. Zhao, Department of Pharmacology, Toxicology & Neuroscience,
Louisiana State University
- To investigate whether Protandim can suppress tumor formation by
a dietary approach, a two-stage mouse skin carcinogenesis study was
performed. At the end of the study, both skin tumor incidence and
multiplicity were reduced in the mice on the Protandim diet by 33%
and 57% respectively compared with those on a basal diet.
- *Induction of antioxidant enzymes by Protandim may be practical
for cancer prevention.
Chronic Pulmonary Artery Pressure Elevation is
Insufficent to Explain Right Heart Failure
- Publication:Circulation, Nov. 17, 2009
- Authors: H.J. Bogaard, R. Natarajan, S.C. Henderson, C. S. Long,
D. Krakauskas, L. Smithson, R. Ockaili, J.M. McCord, N.F. Voelkel,
Divisions of Pulmonary and Critical Care, Virginia Commonwealth
University
- This study used a lab model of pulmonary hypertension in rats to
explore factors contributing to heart failure in animals. Pulmonary
hypertension was induced in rats through a drug and by creating an
oxygen-poor environment. The animals pre-treated with Protandim
experienced strong cardio-protectitive effects.
- *Protandim protected the animal's hearts by increasing the
expression of protective genes and preventing the formation of scar
tissue.
The Chemopreventive Effects of Protandim: Modulation of
p53 Mitochondrial Translocation and Apoptosis During Skin
Carcinogenesis
- Publication:PLoS One, July 30, 2010
- Authors: D. Robbins, X. Gu, R. Shi, J. Liu, F. Wang, J.
Ponville, J.M. McCord, Y. Zhao, Department of Pharmacology,
Toxicology and Neuroscience, Louisiana State University Health
Sciences
- This study explored the biochemical mechanisms that underlie the
ability of Protandim to suppress tumors in mice. That ability was
previously demonstrated by the authors in a study involving a mouse
two-stage model of chemically-induced skin cancer. This study
suggested that suppression of p53 and induction of MnSOD may play
an important role in the tumor suppressive activity of
Protandim.
- *The induction of antioxidant enzymes by Protandim may be a
practical and potent approach for cancer prevention.
Synergistic Induction of Heme Oxygenase-1 by the
Components of the Antioxidant Supplement Protandim
- Publication:Free Radical Biology & Medicine, Feb. 1,
2009
- Authors: K. Velmurugan, J. Alam, J.M. McCord, S. Pugazhenthi,
Division of Endocrinology, Department of Medicine, University of
Colorado Denver
- This study explored whether components of Protandim acted in a
synergistic manner in certain cells, specifically if it would
induce heme oxygenase. When components were tested alone, only
curcumin showed minimal induction. Together they produced a strong,
synergistic induction.
- *Protandim produced a 300% increase in glutathione, a key
antioxidant and anti-aging factor. Also, the supplement's patented
formula provides a strong synergy much greater than the sum of its
parts.
* Source: PUBMED.GOV
Protandim is a dietary supplement, not a drug. We do not promote
or intend to imply or represent that Protandim can prevent, cure,
treat or mitigate any disease or class of disease. Protandim is not
intended to be an alternative or replacement for any drug or
biological product. If you are interested in reviewing the studies,
visit www.pubmed.gov and enter
"Protandim" in the search box.